Keith has had a longstanding interest in wound healing. He was appointed as the first Director of the Wound Healing Research Unit in 1991. From September 2013 to December 2018 he was Dean of Clinical Innovation at Cardiff University and in 2014 was appointed as Medical Director of the Welsh Wound Innovation Centre.

He is the Editor-in-Chief of the International Wound Journal. He was the First President of the European Pressure Ulcer Advisory Panel, First Recorder of the European Wound Management Association and is a Past President of the European Tissue Repair Society.

He was awarded the CBE in the New Year Honours list in January 2013 for Services to Medicine and Health Care. In 2013 he was awarded £4.2 million to set up the Welsh Wound Innovation Initiative part of which has enabled the setting up of the first Wound Healing Centre in the World. In 2018 he was appointed as a Senior Clinical Research Director at the A Star Institute in Singapore and is part of a SG$ 28 million wound programme grant.