Project duration: 18 months

PartnersClinical Innovation Accelerator (Cardiff University), Siemens Healthcare
Diagnostic Products, and Cardiff and Vale University Health Board

Project aim: To develop new commercial immunoassays for precision medicine-based diagnosis of acute infections, and ultimately sepsis

A photo of siemens machine

Project overview

Following a diagnosis of colorectal cancer, 63% of patients will undergo a colorectal resection with most patients having an anastomosis. The risk of infection due to an anastomosis leak can be up to 20%, which can result in sepsis – a life threatening condition which has a high mortality and morbidity profile. There is also some evidence suggesting that a leak could increase the risk of local cancer reoccurrence.

Despite the significant consequences of an anastomotic leak, there has been little advance in the development of early diagnostics. The placement of surgical drains near the anastomosis provides a unique window to the local site of inflammation and allows repeated convenient, non-invasive sampling of relevant biological specimen.

A highly sensitive and specific bedside test for drain fluid would be a considerable diagnostic improvement for patients undergoing abdominal surgery and could help with the identification and the treatment of those who are at risk of an anastomotic leak.

This project is focusing on localised infections resulting from anastomotic leaks in order to establish immune fingerprints in patients undergoing colorectal surgery with anastomosis.

Accelerate's involvement

  • Develop an accurate diagnostic test based on immune fingerprints for the early detection and characterisation of anastomotic leaks and sequelae
  • Identify correlations between localised and systemic immune responses in patients with acute infection
  • Utilise artificial intelligence to interrogate biomedical datasets

Professor Jared Torkington, Consultant Colorectal Surgeon and Assistant Medical Director at Cardiff and Vale UHB said:

“We have concentrated our research work on projects that have the potential to quickly become game changing for patients and improve the outcomes from cancer surgery. It is such an exciting opportunity to be working within a team that shares the same vision”.

Expected outcomes

  •  Healthcare benefit to patients in Wales through:
    • Better management of infection risk
    • Improved care and wellbeing of cancer patients in the long term
  • New diagnostic test systems for Siemens
  • New employment at Siemens
  • Economic impact through earlier improvement in the health and wellbeing of patients
  • Machine learning techniques to enhance the development of diagnostic tests
  • Data to underpin further academic research collaborations
  • Academic publications and case studies

Future impact

  • Strategic partnership between Siemens and Cardiff University in diagnostics
  • Increased R&D capabilities
  • Further collaborations between industry, academic and clinical partners